Estradiol Information

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Usage: Estradiol (a form of estrogen) is a female sex hormone necessary for many processes in the body. Estradiol vaginal products release estrogen that is absorbed directly through the skin of the vaginal wall. Estradiol topical is used to treat certain symptoms of menopause such as dryness, burning, and itching of the vaginal area and urgency or irritation with urination.

Directions: Use Estradiol exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Have yearly physical exams and examine your breasts for lumps on a monthly basis while using Estradiol.

Side Effects: Estradiol increases the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, while using Estradiol lowers the risk of developing this condition. Therefore, if your uterus has not been removed, your doctor may prescribe a progestin for you to take together while using Estradiol. Visit your doctor regularly and report any unusual vaginal bleeding right away. Treatment with Estradiol long-term may increase the risk of stroke. Because of this risk, you should contact your doctor or healthcare provider to discuss your individual risks and benefits before taking Estradiol long-term. You should also talk to your doctor or healthcare provider on a regular basis (for example, every 3-6 months) about whether you should continue this treatment. If you experience any of the following serious side effects, stop using Estradiol and seek emergency medical attention: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); shortness or breath or pain in the chest; a painful, red, swollen leg; abnormal vaginal bleeding; pain, swelling, or tenderness in the abdomen; severe headache or vomiting, dizziness, faintness or changes in vision or speech; yellowing of the skin or eyes; or a lump in a breast. Other, less serious side effects may be more likely to occur. Continue to use Estradiol and talk to your doctor if you experience decreased appetite, nausea, or vomiting; swollen breasts; acne or skin color changes; decreased sex drive; migraine headaches or dizziness; vaginal pain, dryness, or discomfort; water retention (swollen hands, feet, or ankles); depression; or changes in your menstrual cycle or break-through bleeding.

Precautions: There are no restrictions on food, beverages, or activity while using Estradiol unless your doctor directs otherwise.

Drug Interactions: Before using Estradiol, tell your doctor if you are taking any of the following medicines: an anticoagulant (blood thinner) such as warfarin (Coumadin); a thyroid medication such as levothyroxine (Synthroid, Levoxyl, Levothroid, and others); insulin or an oral diabetes medicine such as glipizide (Glucotrol), glyburide (Diabeta, Micronase), and others; or tamoxifen (Nolvadex). A dosage adjustment or special monitoring may be required during treatment if you are taking any of the medicines listed above. Do not use other vaginal products at the same times as Estradiol without first talking to your doctor. Drugs other than those listed here may also interact with Estradiol. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

If You Take Too Much: An overdose of Estradiol is unlikely to occur and is not likely to threaten life. If you do suspect an overdose, or if the medication has been ingested, call an emergency room or poison control left for advice.

Missed Dose: Take the missed dose as soon as you remember. Continue to follow your regular schedule. Do not use two doses simultaneously unless your doctor directs otherwise.

Storage: Store Estradiol at room temperature away from moisture and heat.




 
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