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Usage: Zyloprim is used in the treatment of many symptoms of gout, including acute attacks, tophi (collection of uric acid crystals in the tissues, especially around joints), joint destruction, and uric acid stones. Gout is a form of arthritis characterized by increased blood levels of uric acid. Zyloprim works by reducing uric acid production in the body, thus preventing crystals from forming. Zyloprim is also used to manage the increased uric acid levels in the blood of people with certain cancers, such as leukemia. It is also prescribed to manage some types of kidney stones.
Directions: Take Zyloprim exactly as prescribed. Your doctor will probably start you on a low dosage, increasing it gradually each week until you reach the dosage that is best for you. A typical starting dose is one 100-milligram tablet per day. You may want to take Zyloprim immediately after a meal to minimize the risk of stomach irritation. You should avoid taking large doses of vitamin C because of the increased possibility of kidney stone formation. While taking Zyloprim you should drink plenty of liquids--10 to 12 glasses (8 ounces each) per day--unless otherwise prescribed by your doctor. To help prevent attacks of gout, you should also avoid beer, wine, and purine-rich foods such as anchovies, sardines, liver, kidneys, lentils, and sweetbreads. If you have been taking colchicine and/or an anti-inflammatory drug, such as Anaprox, Indocin, and others, to relieve your gout, your doctor will probably want you to continue taking Zyloprim while your Zyloprim dosage is being adjusted. Later, when you have had no attacks of gout for several months, you may be able to stop taking these other medications. If you have been taking a drug that promotes the excretion of uric acid in the urine, such as probenecid (Benemid) or sulfinpyrazone (Anturane), to try to prevent attacks of gout, your doctor will probably want to reduce or stop your dosage of Zyloprim while increasing your dosage of Zyloprim.
Side Effects: Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Zyloprim. Because a skin reaction, the most common side effect of Zyloprim, may occasionally become severe or even fatal, you should stop taking Zyloprim if you notice even the beginnings of a rash. Such a rash may be itchy or scaly or may make your skin peel off in sheets; it may be accompanied by chills and fever, aching joints, or jaundice. More common side effects may include: Acute attack of gout, diarrhea, nausea, rash.
Precautions: If you notice a rash or other signs of an allergic reaction, stop taking Zyloprim immediately and consult your doctor. In some people, a Zyloprim-induced rash may lead to a serious skin disease, generalized inflammation of a blood or lymph vessel, irreversible liver damage, or even death. You may experience acute attacks of gout more often in the early stages of Zyloprim therapy, even when normal uric acid levels have been attained. These attacks will become shorter and less severe after several months of therapy. A kidney problem may turn a normal dose of Zyloprim into an overdose. If you have a kidney disease, or a condition such as diabetes or high blood pressure that may affect your kidneys, your doctor should prescribe Zyloprim cautiously and order periodic blood and urine tests to assess your kidney function. Because Zyloprim may make you drowsy, do not drive or perform hazardous tasks until you know how the medication affects you. It may be 2 to 6 weeks before you see any results from Zyloprim.
If You Take Too Much: Although no specific information is available regarding Zyloprim overdosage, any medication taken in excess can have serious consequences. If you suspect an overdose of Zyloprim, seek medical attention immediately.
Missed Dose: Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at once.
Storage: Store at room temperature in a cool, dry place, away from light.
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